The first recorded encounter of the Karankawa occurred in 1528. Álvar NúñezCabeza de Vaca describes his encounter in his book, La Relacion. 

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In his account, he describes the time he spent with the Karankawa for approximately six years. Cabeza de Vaca was considered a slave but was treated well. He along with three remaining survivors escaped the Karankawa and made their way across Texas and eventually reached the Spanish Colony of Mexico. 

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